Endocrine Abstracts

Introduction: Acromegaly is an endocrinopathy that affects many different organ systems and leads to multiple comorbidities. Data on morphologic pathology of kidneys in acromegaly is scarce.Methods: We investigated 19 acromegalic patients (11 male, mean age 57.8±12.1 years) presenting in our outpatient clinic. We evaluated each patient’s kidneys by ultrasound, measuring organ dimensions and volume as well as noting any pathologic findings.<...

Adrenal vein sampling (AVS) is a technically demanding procedure required for identification of suitable candidates for unilateral adrenalectomy in primary aldosteronism. Recently, somatic mutations in aldosterone producing adenomas (APA) have become a focus of research. We identified KCNJ5 K+-channel mutations in 34% of APAs, and more recently mutations in 2 ATPase family members in 11 and 6%. However, it is unclear whether steroid gradients during the AVS are infl...

Context: Primary aldosteronism (PA) represents the most frequent cause of a curable secondary arterial hypertension. Conflicting data have been published regarding the effect of aldosterone excess on glucose and lipid metabolism.Objective: Our aim was to analyze insulin sensitivity and beta cell function in a cohort of PA patients. Prospective follow-up investigations were performed in a subgroup of patients before and after adrenalectomy to assess the m...